Catecholamines Stimulate Renal Gluconeogenesis through an al-Type of Adrenoceptor
نویسندگان
چکیده
1. Noradrenaline stimulates gluconeogenesis through an (a-adrenoceptor in renal cortical tubule fragments from fed rats incubated with 5 mM-lactate. 2. The selective a1-adrenoreceptor agonist methoxamine stimulated gluconeogenesis, but the selective a2-adrenoceptor agonist clonidine was ineffective. 3. The selective a1-adrenoceptor antagonist thymoxamine blocked the stimulatory effects on gluconeogenesis of noradrenaline and of oxymetazoline (a synthetic a-agonist). The selective a2adrenoceptor antagonist yohimbine was ineffective in this respect. 4. It is concluded that noradrenaline and oxymetazoline stimulate gluconeogenesis in rat kidney via an a1rather than an a2-type of adrenoceptor.
منابع مشابه
Evidence for stimulation of renal gluconeogenesis by catecholamines.
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